Vitro Biopharma develops Wharton’s jelly of the umbilical cord-derived cell therapies to modulate the immune system and inflammation. Umbilical Cord MSCs are the youngest, most potent adult stem cells known, free from age related issues, prior medical conditions and genetics that come with use of adipose or bone-marrow-derived MSCs. UC-MSCs are significantly superior in multiple categories to other adult stem cells, including the ability to differentiate into neural stem cells (NSCs), adipose and bone-marrow-derived MSCs do not.

Our extensive knowledge of immunology and inflammatory conditions informs our decision making to advance the scientific and clinical path to demonstrate proof-of-concept, with the goal of achieving an efficient timeframe and cost-effective budget.

The mechanisms of action involve immunomodulation that reduces patient immune response to myelin basic protein. Negative regulation of T-cells through secretion of IDO (indolamine dioxygenase) by the conversion of tryptophan to kynurenine that directly inhibits T-cell proliferation. Further MSC-induced up-regulation of TREG cells by TGF-beta secretion from MSCs also suppresses immunity through regulation of dendritic cells. Other mechanisms include cellular repair of demyelination by cellular repair through paracrine effects that repair damaged neurons as evidenced by resolution of plaques by MRI imaging. Anti-inflammatory mechanisms are also likely including MSC-induced shift of M1 pro-inflammatory macrophages to M2 anti-inflammatory macrophages and secretion of PGE2 from MSCs that up-regulates dendritic cells to secrete anti-inflammatory cytokine IL-10 and decrease secretion of pro-inflammatory cytokines TNGF-alpha and IL-12.

Modulate Inflammation

Respond to excessive
pro‐inflammatory signals via receptors
for TNF‐α, IFN‐γ and
IL‐1β

Comparative Analysis

There are multiple characteristics of umbilical cord MSCs significantly superior to those derived from adipose, bone marrow or placental tissues.

Superior Potency

Superior potency by mitochondrial and immuno-suppression measurement.

Profile

UC-MSCs have cellular functional advantages in migration, proliferation, yield, secretion properties and viability.

Scalable Manufacturing: Key Competitive Advantage

We have developed several novel cell culture media formulations through over 25 years of stem cell research. We now offer various formulations for both stem cells and primary cell culture that feature numerous competitive advantages. These include faster growth, resulting in significantly greater cellular yield, higher quality and potency, vastly improved stability and complete formulations without the necessity of mixing prior to use.