Whatever the project, capacity or timescale, we are there to help you to get the optimum out of your cell culture.

Animal Free
Fully Defined
Reliability
Performance
Flexibility


Products

Animal Free

Free from animal and human derived compounds / Fully ACF.

During the last decades the regulatory pressure to move away from the use of FBS has become ever bigger since the risk of contaminations with viruses and prions, and the need for traceability records. TNCBio supports the demand for a chemically defined and fully animal component free replacement for FBS by presenting XerumFree™, an efficient and fully defined cell culture supplement for serum free cell culture.

The composition of XerumFree™ is guaranteed free from any product derived from animal or human material. XerumFree™ has an ultra low protein content. The proteins in XerumFree™ are from recombinant source only and these proteins are  produced by a recombinant bacterial process in ACF media.

Reliability

You cannot afford unexpected situations that can cause gaps in your vaccine production, regarding supply, cost and quality. The consistency of the quality of XerumFree™ is guaranteed by the fact that it is fully defined and fully ACF. Furthermore the risk of supply chain breakdown is virtually null because TNCBio takes also care for the consistency in supply of XerumFree™ to your production facilities.

TNCBio’s manufacturing facilities are prepared for high volume productions and can be flexibly scaled up on demand. The raw materials used for the production of XerumFree™ are not sensitive to volatility, fluctuations and availability of the world market.  This guarantees a constant production and supply of XerumFree™ to the customers of TNCBio, a promise we can put in contract with fixed pricing also.

With this, we provide you with a carefree serum free cell culture. For applications in viral vaccine production and development, cell therapy and many others.

Fully Defined

Fully defined is the best way to the same quality for every batch.

Many products in the market that are offered as alternatives for FBS are compositions that contain hydrolysates, plant extracts and/or animal or human proteins like albumins. This can affect the consistency from batch to batch in a negative way and lowers the control over the culture environment and makes further rational optimization steps difficult to perform.

XerumFree™ consists only of compounds that are each a highly purified chemical from either synthetic or recombinant origin. This guarantees an extremely high consistency from batch to batch and a full traceability record. You can be sure that the XerumFree™ that you use today in your R&D or in your production is exactly the same as the XerumFree™ you will use in the future on short and long term.

Performance

Every single change in your production needs to increase your output, whether it is quality wise or in quantity or both. Besides bringing features as constant and safe quality to your process, XerumFree™ has shown in production environments were it was tested that cell output was comparable or higher compared with either FBS or other undefined media.

Flexibility

Standard packaging of XerumFree™ for R&D is 100 and 500 ml Nalgene PETG bottles. For production purposes where volume is higher we deliver virtually every packaging you might require. Being it bags or vessels; as as long as we can source them we can deliver it.

Products

Defined cell culture

XerumFree is a fully defined additive, avoiding the need for serum, for a wide range of cell culture practices. Since XerumFree is chemically defined it avoids lot-to-lot variations. All components in XerumFree are highly purified and identified chemical compounds.

XerumFree Benefits
Culturing cells in a XerumFree enriched medium represents a number of benefits as compared to conventional FBS enriched media.

  • Due to its chemically defined nature there are no lot-to-lot variations. This skips the need for testing new batches of serum.
  • There is no interference of unknown serum compounds in your research
  • Since it doesn’t contain hormones nor cytokines it doesn’t bias your research data
  • XerumFree is save in use, since it doesn’t contain animal or human derived materials
  • It can be stored in the refrigerator. No need for thawing before use.        

Defined cell culture

CHO cells are the most widely used mammalian cells in bioprocess production of recombinant proteins.

CHOiXTM is a fully defined and animal/human component free medium for optimal cell growth and expression of CHO cells.

CHOiXTM is applicable in both R&D projects as for further manu- facturing . The balanced formulation facilitates optimal and high density cell growth as well as a high viability of the cells.

The defined and ACF composition of CHOiXTM makes down- stream processes much easier and highly economic.

XF501 Defined Endothelial Cell Growth Kit

XF501 Defined Endothelial Cell Growth Kit is a complete medium for the optimal growth of endothelial cells from large vessels. The kit contains a medium with essential and non-essential amino acids, vitamins, organic and inorganic compounds etc. Additionally the kit contains an optimized combination of growth factors, hormones and a growth supplement.

By using this kit for the growth of endothelial cells there is no need to use FBS or other sera. All components in the kit are free of animal and/or human derived materials.

The XF501 Defined  endothelial Cell Growth Kit is for in vitro research applications only.

References