FormuMax has been providing custom-made formulations of liposomal doxorubicin HCl with various lipid compositions and particle sizes. There has been an increased demand of liposomal doxorubicin comparable to the commercial Doxil®. Now we are proudly naming our product, Doxoves®, and making it available to you at an affordable price.

Doxoves® is manufactured to high quality with consistent lot-lot characteristics, tight particle size distribution and high drug encapsulation efficiency. A high drug concentration of 4.0 mg/mL (40mM lipid) allows researchers to perform experiments at higher concentrations/doses. Doxoves® is comparable to the commercial product Doxil® in characteristics, stability and pharmacokinetics. Cryo-TEM studies have shown that the encapsulated doxorubicin forms the same type of rod-like structures as in Doxil®. A recent PK study of two batches of Doxoves® demonstrated an excellent PK profile with t1/2 of 30-40hr similar to that of Doxil®.

Formumax currently offer two types of preformed liposomes for drug loading. The ammonium sulfate gradient liposomes for loading weakly basic small molecules and the other being liposomes for loading hydrophobic (lipophilic) compounds.

FormuMax offers a series of cationic liposomes. They can be used as positively charged liposomes or as cell transfection reagents for plasmid DNA, antisense, siRNA, etc. Please contact us if you require any product not shown below.

We are very excited to announce the introduction of our brand new product, Trans-HiTM, as a superior transfection reagent to compete against the leading products in the market. Trans-HiTM is created based on a proprietary polymer technology. It forms stable complex particles with DNA and rapidly releases the DNA molecules upon endocytosis into the cytoplasm. It offers superior and reproducible transfection efficiency on the common cells such as Hela, CHO, HEK293 and many hard-to-transfect mammalian cells with minimal toxicity. Trans-HiTM is very cost-efficient and 1.0mL is sufficient for over 650 transfections in 24 well plates.

Trans-Hi™ – In vitro Transfection Reagent Cat# F90101TH-10 – 0.5 mL 1.0 mL 10 x 1.0 mL
Trans-Hi™ – Transfection Reagent Evaluation Sample cat# F90101TH-00

Contact technical@stratech.co.uk for more information

FormuMax offers preformed fluorescent liposomes labeled with lipophilic dyes at affordable prices. The 100nm series has becoming increasingly popular. We are also adding other sizes such as the 200nm and 500nm fluorescent liposomes to satisfy the need for particle size standards in the field of flow cytometry. Our liposomes are produced by the extrusion technology which is known to produce the most uniform liposomes. However customers should be aware that liposomes prepared by the extrusion method still have rather broad particle size distribution. The particles size reported in the product sheet is for the mean diameter as measured by a standard DLS particle sizer.

100nm Fluorescent Liposomes

200nm Fluorescent Liposomes

300nm Fluorescent Liposomes

FormuMax offers pre-formed liposome reagents to research organizations involved in liposomal drug delivery. We offer a large number of common lipid compositions, prepared by experienced formulators using only the highest quality lipids from premier suppliers. Our products are easy to use, time-saving, and cost-saving, improving the productivity and reliability of your research. They are highly trustworthy for batch-to-batch consistency and reproducibility, and are sterile-filtered and properly packaged in vials to ensure long-term stability when stored refrigerated.

Please feel free to contact us if you do not find the specific preformed liposome of your interest. We also provide custom liposomes made to your specifications.

FormuMax offers a list of lpharmaceutical actives encapsulated in liposomes. Currents products is shown in the list below and we will continue to add more products in the future depending on the demond.

• Specialized in liposome encapsulation of difficult compounds

• Encapsulation of small molecules, peptides/proteins, nucleic acids

• Solubility enhancement using liposomes and lipid-based systems

• Liposomes and other lipid-based drug delivery systems

• Controlled/slow drug release systems

• Nanocrystal down-sizing and polymer coating

• Pre-formulation, formulation feasibility, and prototype development

• Scale-up, composition/process optimization (Design-of-Experiments)

• Extrusion, homogenization/microfluidization, sonication and others

• Formulation characterization, stability, in vitro/in vivo studies

• Freeze-drying and lyophylization

• Particle size and distribution by DLS (Brookhaven ZetaPALS)
• Zeta Potential and Mobility (Brookhaven ZetaPALS)
• Particle size, distribution and particle concentration by qNano (directly measures the properties of individual nanoparticles in solution)
• Drug encapsulation efficiency (free drug separated and assayed by HPLC or other analytical means)
• Lipid/liposome phase transition, enthalpy (MicoCal VP-DSC)
• Polymer glass transition, melting point (Perkin Elmer DSC 7)
• Lyophylization/Freeze trying (Virtis Genesis)
• Formulation examination under microscope

• HPLC method development (Agilent 1100 HPLC, Waters 2695)
• HPLC measurement of drug potency and degradents
• Lipid assay
• Drug assay (HPLC, UV SpectraMax plate reader, SpectraMax Gemini XS plate reader)
• Formulation stability (chemical and physical)
• Lipid/liposome phase transition, enthalpy (MicoCal VP-DSC)
• Polymer glass transition, melting point (Perkin Elmer DSC 7)
• In vitro drug release assay
• pH
• Osmolarity (Wescor Vapro Osmometer 5520 and OSMETTE XL™ 5007 )
• Viscosity (Brookfield DV-II+Pro)
• Refractive Index