Creative Enzymes is one of the few companies in the world that have the ability to supply a variety of zymogens. We are proudly composed of groups of brilliant scientists who are devoting themselves to high-grade products and satisfying services. Our products include different types of zymogens: human zymogens, bovine zymogens, and mouse zymogen. As a renowned supplier, Creative Enzymes offers the products with high quality and competitive cost performance. The unique and superior products distinguish Creative Enzymes from our competitors.

Zymogens are a group of proteins that display no catalytic activity but can be transformed into active enzymes within an organism. A zymogen is an inactive precursor of an enzyme, especially those that catalyze reactions involving the breakdown of proteins. Zymogens require a biochemical change, such as the change of configuration or a hydrolysis reaction to reveal the active site, to become an active enzyme. For this reason, a zymogen is also called a proenzyme.

Zymogens, rather than active enzymes, are typically secreted by the human body, because they can be stored and transported safely without harms to surrounding tissues, and released when conditions are favorable for optimal activity. Most of the digestive proteases produced in the pancreas are expressed as zymogens and retained in such form in zymogen granules. The contents of these granules are only released into the small intestine during eating, and the zymogens are only activated once they enter the small intestine. The latter step is initiated by an intestinal protease, enterokinase. For example, pepsin is synthesized in the form of pepsinogen, an inactive zymogen which is secreted by the chief cells. Pepsin becomes active once pH drops below 5, and works optimally at pH 2-3 in the acidic environment of the stomach. Activation of pepsinogen starts with the hydrocholoric acid (HCl), which is secreted by the parietal cells. The acid partially activates pepsinogen by drastically lowering pH. The partially activated pepsinogen is then completely activated and turned into pepsinby another pepsinogen through cleavage of a short peptide. Under rare circumstances, incorrect activation of these zymogens within the pancreas could result inpancreatitis and lead to devastating consequences.

Creative Enzymes serves the customers with all kinds of zymogens, which can be classified into three different sources: human, bovine, and mouse. Each species then can be subdivided into either one or more types of enzyme cascades, such as the coagulation cascade of prothrombin or protein C. The purity of all these products is above 90%, which is determined by SDS-PAGE analysis. These zymogens are considered to play critical roles in various biochemistry reactions such as calcium ion binding, peptidase activity, phospholipid binding, protein binding, and serine-type endopeptidase activity.

For many years, Creative Enzymes has been manufacturing and distributing a variety of enzymes and zymogens used in multiple research areas. By constantly striving for utmost quality, Creative Enzymes has earned the trust of countless customers, and is proud to offer highly sophisticated research products. Creative Enzymes is committed to achieving the highest level of customer satisfaction, and to continuously improving its products, services, and quality management.

Creative Enzymes provides enzyme products covering multiple directions in development and researching. Our excellent techniques guarantee high-quality products. Enzymes are now known to catalyze more than 5,000 biochemical reactions, and the chemical essential of most enzymes are proteins. Enzymes exist in all organisms and perform an important role in life activities. A majority of enzymes have been used in the chemical industry and medical research. Due to the many advantages of enzyme-catalyzed reactions, including specificity, efficiency, and mild conditions, which differ from chemical catalysis, enzymes become a most promising catalyst in all applications.

Creative Enzymes offers a variety of enzyme products for applications in different areas, including industrial uses, research uses, and medical uses. The products are manufactured with strict quality assurance, which generates top-rated purity to support your studies in every application.

 Industrial Enzymes

Creative Enzymes provides enzyme products for industrial uses. In the food industry, the production of food and beverages prefer enzymatic processes to achieve food-grade ingredients and products. We offer a wide range of enzymes that are suitable for virtually all steps in food products. Besides for human food, enzymes for production of animal feed are also available, which gives makes natural and healthy choices accessible for pets and stock lives. For daily necessities, we have large production capacity for enzyme products related to household cleaning, personal care, textiling, leather processing, and pulp and paper bleaching and degradation applications. In an even larger scale, we are also capable of manufacturing enzymes for agriculture, waste management, material recycling, and chemical synthesis and processing. Our enzyme products cover most areas in industrial uses, and the products are available in a variety of specifications and scales. Please contact us to find the product that best fits your exact need.

Medical Enzymes

Creative Enzymes offers enzyme products to support medical research and the development of medical products. Our enzyme products include digestive, diagnostic, and pharmaceutical enzymes. Digestive enzymes are enzymes that break down polymeric macromolecules to make the nutrition more readily to intake. We offer native digestive enzymes, or recombinant and modified enzymes that show high consistency with natural enzymes in functions and properties. The diagnostic and pharmaceutical enzymes are used in therapeutic and clinical areas as the essential tool to detect fluctuations and changes in key metabolites, signaling molecules, and even enzymes, which further indicate any possible abnormality in biological functions. Use of these enzymes requires the highest level of purity and specificity beyond the average quality. The medical enzyme products provided by Creative Enzymes will certainly meet all the stringent requirements and significantly expedite medical services and business.

Research Enzymes

Creative Enzymes provides various native enzymes from a variety of species, including plants, microorganisms, and mammals. We also provide recombinant enzymes through microorganism expression. The products are of the top quality in the industry, relying on our specialized techniques and professional development and operation teams. Our commercialized products are approved by researchers and innovators for the stable catalytic activities and high purity. These enzyme products include oxidoreductases, transferases, hydrolases, lyases, isomerases, and ligases. Different levels of specifications are available for these products to meet various requests from the customers.

Creative Enzymes provides high-quality enzyme products backed by our unique technologies. We have manufacturing and development felicities run by specialized teams following the most up-to-date industrial standards. This leads to exceptionally high quality and stable activities of our products. Creative Enzymes never stop developing new enzymes for the ever-changing market. In the future, we will keep the supply of reliable enzyme products to support your industrial applications and experimental research.

Creative Enzymes is an innovative company that has developed new technologies to manufacture a series of coenzyme products. We are proud to provide products of utmost quality and the most reliable service to our customers. Creative Enzymes supplies various coenzymes which include nicotinamide adenine dinucleotide (NAD), flavin adenine dinucleotide (FAD), adenosine diphosphate (ADP), coenzyme A (CoA), thiamine pyrophosphate (TPP), pyridoxal phosphate (PLP), tetrahydrofolate, coenzyme B, biotin, and so on.

Definition of Coenzymes

A coenzyme is a small organic molecule, but not a peptide, that binds to an enzyme and whose presence is essential to the activity of the enzyme. It is considered to be an assistant molecule for biochemical reactions. Coenzymes provide a transfer site for a functioning enzyme in most cases. It often functions as an intermediate carrier of electrons, specific atoms, or functional groups, allowing a reaction to occur. Coenzymes are usually not a part of an enzyme’s structure or the substrate of the reaction. The coenzyme may either be a prosthetic group— a tightly bound coenzyme—or a co-substrate, which is a loosely bound small organic molecule. An inactive enzyme without the cofactor is called an apoenzyme, while the complete enzyme with cofactor is called a holoenzyme.

Coenzymes, Cofactors, and Prosthetic Groups

Some textbooks regard all assistant molecules that bind to an enzyme as cofactors, while others divide these chemicals into three groups:

• Coenzymes are small non-protein, organic molecules that bind to an enzyme. Many coenzymes are vitamins or derivatives of vitamins. While some other coenzymes are built around adenosine monophosphate (AMP).
• Cofactors are small non-protein chemicals or metallic ions that can aid an enzyme function and increase the rate of the catalytic reaction. Cofactors can be subdivided intoin organic ions, complex organic molecules, and metallo-organic molecules which can also be called coenzymes. A cofactor that is tightly or even covalently bound to an enzyme is sometimes termed as a prosthetic group. Typical cofactors are considered to be the metal ions. Even some metallic elements have no nutritional value, several trace elements function as cofactors in multiple biochemical reactions, such as iron, zinc, magnesium, and copper. However, some trace elements that play a part in nutrition do not appear to act as cofactors, including chromium, iodine, and calcium.
• Prosthetic groups are organic partner molecules that bind tightly or covalently to the enzyme and participate in the catalytic cycles of enzymes, such as Flavin adenine dinucleotide (FAD).

Overall, different sources give various definitions of coenzymes, cofactors, and prosthetic groups. Some consider the tightly bound organic molecules as prosthetic groups and not as coenzymes, while others define all non-protein organic molecules bind to enzymes as coenzymes and classify those that are tightly bound as coenzyme prosthetic groups. Therefore,it should be noted that these three terms are oftenexchangeableand used loosely.

As a reliable supplier, Creative Enzymes consistently provides the products of utmost quality and competitive cost performance. Our passion for superb and unique products is only exceeded by our excellent reputation in the marketplace. Creative Enzymes has earned the trust of countless customers and never stops pursuing the highest level of customers’ satisfaction.

Creative Enzymes is a leading biotech company which takes responsibility to perfect and simplify your research processes. We supply products specialized for biomedical research, and we are well known for exceptional expertise, professional processes, extraordinary performance, and cost-effective products. All of our products are guaranteed with high purity and technical support.

Lipid is one of the three major substances in organisms with vital biophysical functions. Firstly, lipid is the main storage form of energy and plays a key role in energetic conversion and transportation. Second, lipids contribute to the absorption of the fat-soluble vitamins. Third, lipids are important components of the bio-membrane system. In order to support your research, Creative Enzymes offers a variety of lipid products of different classifications, including phospholipids, sphingolipids, and sterols. In addition, we also provide natural and synthetic lipids as well as other unique lipids to meet special requests.

Phospholipids

Phospholipids are usually composed of fatty acids and glycerol. Besides, they may also contain a phosphoric acid, nitrogen bases, and other substituents. Due to the possession of one hydrophilic head and a non-polar tail, they are also called polar lipids. Phospholipids are amphipathic in nature and can be divided into three groups, phosphoglycerides, phosphoinositides, and phosphosphingosides. Among them, phosphoglycerides are major phospholipids which contain glycerol groups linked with both phosphoric acid and fatty acids.

Sphingolipids

Sphingolipids are a group of lipids which contain a series of aliphatic amino alcohols as the backbone, including sphingosine. Sphingolipids have wide distributions ranging from yeasts to mammals. In signal transmission and cell recognition, sphingolipids have indispensable roles. Once sphingolipids metabolism becomes disordered, it will arouse huge impacts on neural tissues. The simplest sphingolipids are ceramides, which have been found useful in topic medicines and cosmetic products. Glycolipids are a large group of sphingolipids which contain sugar molecules in their structures.

Steroids and Terpenes

Steroids contain the backbone of cyclopentanoperhydrophenanthrene with four hydrocarbon rings in their structures. They widely exist in tissues of animals and plants and have vital significance in living activities. Steroids include sterol and its derivations. Zymosterol, zoosterol, and phytosterol are the three major forms of sterol. Phytosterol is involved in metabolism of plants. Cholesterol, one of the zoosterols, plays an important role in sustaining the physical state of biomembrane. Besides, it is involved in atherosclerosis. Bile acid and vitamin D are the commonly seen sterol derivations, both of which are important to the growth and development.

Terpenes are linear or cyclic hydrocarbons that are chemically related to steroids: they are often the precursor of steroids in biosynthesis. Although terpenes are in small quantities in cell, it has pivotal biology functions in cell signaling, metabolism, and biosynthesis. In addition, terpenes are also useful active ingredients in agricultural pesticides.

Natural, Modified, and Synthetic Lipids

With the development in extraction methods, more possibilities have been provided to exploration on applications of natural lipids. Natural lipids have potentials in food processing and health products manufacturing. However, the structural diversity is limited in natural lipids, as they are generated by organisms for certain biological functions. Therefore, natural lipids are often chemically modified to provide new properties and functions, thus known as modified lipids or semi-synthetic lipids. Modified lipids are useful tools in research, but limited in pharmaceutical and medical applications due to low thermostability and possible contamination from the animal or plant source. Synthetic lipids are chemically prepared from glycerol. The chemical route leads to even more diverse structures and high purity, which satisfy the special needs in the pharmaceutical industry.

Fluorescent Lipids & Bioactive Lipids

Fluorescent and bioactive lipids are involved in the pathological studies, including signal transduction and cell membrane function. These products are attached with additional functions other than the natural functions of lipids, such as fluorescent reporting and signaling and therefore widely used in biological studies and drug development.

Cationic & Neutral Lipids

Some uncommon lipids such as polymerizable lipids, cationic lipids, and neutral lipids are rear to find but critical to some pioneering studies. We provide these unique products to support your innovative research. Our products are available in various specifications and purities.

In general, lipid products are a rising research field due to their physiological functions and chemical characteristics. To facilitate research on various lipids, Creative Enzymes offers high-purity lipid products including phospholipids, sphingolipids, steroids, and terpenes. Some research also needs uncommon lipids to study the structural effects, and Creative Enzyme is able to provide natural lipids, synthetic lipids, and modified lipids to meet such demands. The reliance of our customers drives us to develop more original and special products. We will continue expanding our product list and really hope to provide you the most suitable products.

Creative Enzymes is an innovative company that has developed new technologies to manufacture a series of coenzyme products. We are proud to provide products of utmost quality and the most reliable service to our customers. Creative Enzymes supplies various coenzymes which include nicotinamide adenine dinucleotide (NAD), flavin adenine dinucleotide (FAD), adenosine diphosphate (ADP), coenzyme A (CoA), thiamine pyrophosphate (TPP), pyridoxal phosphate (PLP), tetrahydrofolate, coenzyme B, biotin, and so on.

Definition of Coenzymes
A coenzyme is a small organic molecule, but not a peptide, that binds to an enzyme and whose presence is essential to the activity of the enzyme. It is considered to be an assistant molecule for biochemical reactions. Coenzymes provide a transfer site for a functioning enzyme in most cases. It often functions as an intermediate carrier of electrons, specific atoms, or functional groups, allowing a reaction to occur. Coenzymes are usually not a part of an enzyme’s structure or the substrate of the reaction. The coenzyme may either be a prosthetic group— a tightly bound coenzyme—or a co-substrate, which is a loosely bound small organic molecule. An inactive enzyme without the cofactor is called an apoenzyme, while the complete enzyme with cofactor is called a holoenzyme.

Coenzymes, Cofactors, and Prosthetic Groups
Some textbooks regard all assistant molecules that bind to an enzyme as cofactors, while others divide these chemicals into three groups:

• Coenzymes are small non-protein, organic molecules that bind to an enzyme. Many coenzymes are vitamins or derivatives of vitamins. While some other coenzymes are built around adenosine monophosphate (AMP).
• Cofactors are small non-protein chemicals or metallic ions that can aid an enzyme function and increase the rate of the catalytic reaction. Cofactors can be subdivided intoin organic ions, complex organic molecules, and metallo-organic molecules which can also be called coenzymes. A cofactor that is tightly or even covalently bound to an enzyme is sometimes termed as a prosthetic group. Typical cofactors are considered to be the metal ions. Even some metallic elements have no nutritional value, several trace elements function as cofactors in multiple biochemical reactions, such as iron, zinc, magnesium, and copper. However, some trace elements that play a part in nutrition do not appear to act as cofactors, including chromium, iodine, and calcium.
• Prosthetic groups are organic partner molecules that bind tightly or covalently to the enzyme and participate in the catalytic cycles of enzymes, such as Flavin adenine dinucleotide (FAD).

Overall, different sources give various definitions of coenzymes, cofactors, and prosthetic groups. Some consider the tightly bound organic molecules as prosthetic groups and not as coenzymes, while others define all non-protein organic molecules bind to enzymes as coenzymes and classify those that are tightly bound as coenzyme prosthetic groups. Therefore,it should be noted that these three terms are oftenexchangeableand used loosely.

As a reliable supplier, Creative Enzymes consistently provides the products of utmost quality and competitive cost performance. Our passion for superb and unique products is only exceeded by our excellent reputation in the marketplace. Creative Enzymes has earned the trust of countless customers and never stops pursuing the highest level of customers’ satisfaction.