Monoclonal Antibody to MERS-CoV Spike (S) protein (Clone: ABM4A80)

Catalogue Number: 10-10023-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 25 ug
Host name: Mouse
Clone: ABM4A80
Isotype: IgG2b, kappa
Immunogen: A recombinant protein fragment from 358-589 aa of MERS-CoV Spike (S1) protein was used as the immunogen for this antibody. This sequence covers the RBD domain (382-503aa) region.
Application: WB

Description

Description: The MERS-CoV spike (S) protein is a type I transmembrane glycoprotein which contains 1353 amino acids and can be cleaved into two subunit S1 and S2. It forms large protruding spikes on the surface of the virus. The S1 subunit which contains RBD is responsible for binding to Dipeptidyl peptidase 4, which serves as the host cell receptor of MERS-CoV and S2 mediates the membrane fusion. In this process, heptad repeats 1 and 2 (HR1 and HR2) of the S protein assemble into a complex called six-helix bundle (6-HB) fusion core structure, which represents a key membrane fusion architecture. Importantly, the S protein is considered a key component of vaccines against coronavirus infection, including severe acute respiratory syndrome (SARS).

Additional Text

Purification

Protein G purified

Antibody Clonality

Monoclonal

Application Notes

Western blot analysis: 0.5-1 µg/ml

UniProt ID

A0A0U2MS74

Storage Note

Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.