Monoclonal Antibody to TLR6 (Clone: ABM1B50)

Catalogue Number: 10-3002-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Alias:TLR6
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 25 ug
Host name: Mouse
Clone: ABM1B50
Isotype: IgG1, kappa
Immunogen: A partial length recombinant TLR6 protein (amino acids 280-512) was used as the immunogen for this antibody.
Application: FACS, WB

Description

Description: TLR6 (Toll-Like Receptors 6) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR6 forms heterodimers with TLR1 and TLR2, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infection with these pathogens. TLR2 in co-operation with TLR6 trigger inflammatory responses via activation of NF-kappaB, which regulates the transcription of inflammatory molecules. TLR6 has emerged as the most potent activator for ZNPs (Zinc Oxide Nanoparticles)-induced inflammatory responses. Upon silencing, TLR6 significantly inhibited the pro-inflammatory cytokine levels, reactive nitrogen species generation and inducible nitric oxide synthase expression.

Additional Text

Gene ID

10333

Gene Name

TLR6

Purification

Protein G purified

Uniprot ID

Q9Y2C9

Antibody Clonality

Monoclonal

Application Notes

Western blot analysis: 2-4 µg/ml; FACS analysis: 0.5-1 µg/10^6 cells

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.