Monoclonal Antibody to TLR3 (Clone: ABM15D5)-PE conjugated

Catalogue Number: 10-3004-P-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Conjugated
Alias:TLR3
Shipping Condition:Blue Ice
Unit(s): 100 test
Host name: Mouse
Clone: ABM15D5
Isotype: IgG1, kappa
Immunogen: A partial length recombinant TLR3 protein (amino acids 25-370) was used as the immunogen for this antibody.
Application: FACS

Description

Description: TLR3 (Toll-Like Receptor-3) acts as a major receptor in virus-mediated innate immune response. This protein belongs to TLR (Toll-like receptor) family which comprises of 10-12 type I integral membrane receptor paralogs that recognize pathogen associated molecular signatures and initiate inflammatory responses. TLR3 consist of pathogen-binding ECD (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 specifically senses dsRNA (Double-stranded RNA), an almost universal viral intermediate generated during most viral replications. TLR-3 activation induces multiple cellular antiviral responses, including production of IFN-alpha/beta and up-regulation of the anti-HIV cellular factor APOBEC3G. These are a family of pattern recognition receptors expressed by immune cells, including macrophages.

Additional Text

Gene Name

TLR3

Gene ID

7098

Purification

Protein G purified

Uniprot ID

O15455

Antibody Clonality

Monoclonal

Application Notes

FACS analysis: 0.5-1 µg/10^6 cells

Storage Note

Store the antibody at 4°C, stable for 6 months.