Monoclonal Antibody to TLR3 (Clone: ABM15D5)-PE conjugated
Catalogue Number: 10-3004-P-ABO
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | TLR3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 test |
| Host name: | Mouse |
| Clone: | ABM15D5 |
| Isotype: | IgG1, kappa |
| Immunogen: | A partial length recombinant TLR3 protein (amino acids 25-370) was used as the immunogen for this antibody. |
| Application: | FACS |
Description
Description: TLR3 (Toll-Like Receptor-3) acts as a major receptor in virus-mediated innate immune response. This protein belongs to TLR (Toll-like receptor) family which comprises of 10-12 type I integral membrane receptor paralogs that recognize pathogen associated molecular signatures and initiate inflammatory responses. TLR3 consist of pathogen-binding ECD (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 specifically senses dsRNA (Double-stranded RNA), an almost universal viral intermediate generated during most viral replications. TLR-3 activation induces multiple cellular antiviral responses, including production of IFN-alpha/beta and up-regulation of the anti-HIV cellular factor APOBEC3G. These are a family of pattern recognition receptors expressed by immune cells, including macrophages.
Additional Text
Gene Name
TLR3
Gene ID
7098
Purification
Protein G purified
Uniprot ID
O15455
Antibody Clonality
Monoclonal
Application Notes
FACS analysis: 0.5-1 µg/10^6 cells
Storage Note
Store the antibody at 4°C, stable for 6 months.
10-3004-P Datasheet
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