Monoclonal antibody to MyD88 (Clone: ABM2H20)

Catalogue Number: 10-3012-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Alias:Myeloid differentiation primary response protein MyD88
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 25 ug
Host name: Mouse
Clone: ABM2H20
Isotype: IgG1, kappa
Immunogen: A partial length recombinant protein of human MyD88 (amino acids 13-221) was used as an immunogen for this antibody.
Application: FACS, WB

Description

Description: MyD88 (Myeloid differentiation factor) is an essential adaptor molecule in all TLR (Toll-like receptor) signaling pathways except TLR3. MyD88 is composed of an N-terminal (Death Domain) and a highly conserved C-terminal TIR (Toll/interleukin-1 Receptor) domain. It is found to stimulate IL-1R/IL18R-mediated signaling. MyD88-dependent signaling is also important in the regulation of innate as well as acquired immunity, in particular, T-cell responses, to various microbial pathogens. After activation of TLRs, MyD88 is phosphorylated and subsequently recruits IRAKs (IL-1R Associated Kinases) and other downstream proteins such as TRAF6, finally resulting in activation of the NF-kappaB (nuclear factor kappa B) pathway.

Additional Text

Gene Name

MYD88

Gene ID

4615

Purification

Protein G purified

Uniprot ID

Q99836

Antibody Clonality

Monoclonal

Application Notes

Western blot analysis: 0.1-2 µg/ml; FACS Analysis: 0.5-1 µg/ml

Storage Note

Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.