Monoclonal Antibody to TLR5 (Clone: ABM22G1)

Catalogue Number: 10-3013-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Alias:TLR5||TIL3
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 25 ug
Host name: Mouse
Clone: ABM22G1
Isotype: IgG2a, kappa
Immunogen: A partial length recombinant TLR5 protein was used as the immunogen for this antibody.
Application: FACS, IHC

Description

Description: Toll-like receptor 5 (TLR5) plays a fundamental role in pathogen recognition and downstream signaling to induce effective immunity. It is well expressed in major old tissues including lung, skin, intestine, and spleen. TLR5 is present in synovial of patients with rheumatoid arthritis (RA), act as novel mediator of innate immunity-induced osteoclastogenesis and bone loss. TLR5 is a receptor for flagellin and is present on the basolateral surface of intestinal epithelial cells. It is involved in the migration of intestinal epithelial cells through activation of the p38 MAPK pathway. TLR5-mediated signaling specifically enhanced the maturation of lung dendritic cells. TLR5 influences the progression and outcome of ovarian, sarcoma, and luminal breast tumors. Mutations in TLR5 have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.

Additional Text

Gene Name

TLR5

Purification

Protein G purified

Uniprot ID

O60602

Gene ID

7100

Antibody Clonality

Monoclonal

Application Notes

Immunohistochemical analysis: 10 µg/ml;FACS analysis: 0.5 µg/10^6 cells

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.