Monoclonal Antibody to Mouse TLR3 (Clone: ABM24E5)

Catalogue Number: 10-3017-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Alias:TLR3
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 25 ug
Host name: Rat
Clone: ABM24E5
Isotype: IgG2b, kappa
Immunogen: A partial length recombinant mTLR3 protein (amino acids 180-385) was used as the immunogen for this antibody.
Application: FACS, WB, IHC

Description

Description: Mouse Toll-like receptor 3 (mTLR3) belongs to a family of evolutionary conserved innate immune recognition molecules and recognizes double-stranded RNA, a molecular pattern associated with viral infections. It has seven exons. mTlr3 show high homology to hTLR3 in their predicted cDNA and protein sequences. The intracellular region of mTlr3 has remarkable homology with the same region of others mTlrs. mTlr3 mRNA is ubiquitously expressed in tissues, being expressed highest in spleen, kidney and lung. Its activation by the synthetic ligand polyinosine:polycytidylic acid (poly I:C) or by mRNA rapidly causes growth cone collapse and irreversibly inhibits neurite extension independent of NF-kappaB. The high levels of mTlr3 expression in Mz B cells perhaps contribute to their ability to clear antigen from the blood.

Additional Text

Gene Name

TLR3

Gene ID

142980

Purification

Protein G purified

Uniprot ID

Q99MB1

Antibody Clonality

Monoclonal

Application Notes

Western blot analysis: 2-4 µg/ml, FACS analysis: 0.5 µg/10^6 cells, Immunohistochemical analysis: 10 µg/ml

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.