Monoclonal Antibody to Mouse TLR3 (Clone: ABM24E5)
Catalogue Number: 10-3017-ABO
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Fig-2: Intracellular flow analysis of mTLR3 in m Splenocytes using 0.5 µg/10^6 cells of mTLR3 antibody (Clone: ABM24E5). Green represents isotype control; red represents anti-mTLR3 antibody. Goat anti-Rat FITC conjugate was used as secondary antibody.
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Fig-3: Immunohistochemical analysis of mTLR3 in human Liver tissue using mTLR3 antibody (Clone:ABM24E5) at 10 µg/ml.
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Fig-1: Western blot analysis of mTLR3. Anti- mTLR3 antibody (Clone: ABM24E5) was used at 2 µg/ml on mouse brain lysate.
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | TLR3 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Rat |
| Clone: | ABM24E5 |
| Isotype: | IgG2b, kappa |
| Immunogen: | A partial length recombinant mTLR3 protein (amino acids 180-385) was used as the immunogen for this antibody. |
| Application: | FACS, WB, IHC |
Description
Description: Mouse Toll-like receptor 3 (mTLR3) belongs to a family of evolutionary conserved innate immune recognition molecules and recognizes double-stranded RNA, a molecular pattern associated with viral infections. It has seven exons. mTlr3 show high homology to hTLR3 in their predicted cDNA and protein sequences. The intracellular region of mTlr3 has remarkable homology with the same region of others mTlrs. mTlr3 mRNA is ubiquitously expressed in tissues, being expressed highest in spleen, kidney and lung. Its activation by the synthetic ligand polyinosine:polycytidylic acid (poly I:C) or by mRNA rapidly causes growth cone collapse and irreversibly inhibits neurite extension independent of NF-kappaB. The high levels of mTlr3 expression in Mz B cells perhaps contribute to their ability to clear antigen from the blood.
Additional Text
Gene Name
TLR3
Gene ID
142980
Purification
Protein G purified
Uniprot ID
Q99MB1
Antibody Clonality
Monoclonal
Application Notes
Western blot analysis: 2-4 µg/ml, FACS analysis: 0.5 µg/10^6 cells, Immunohistochemical analysis: 10 µg/ml
Storage Note
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
10-3017 Datasheet
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