Monoclonal Antibody to NALP3 (Clone: ABM2D48)

Catalogue Number: 10-3018-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Alias:NLRP3||C1orf7||CIAS1||NALP3||PYPAF1
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 25 ug
Host name: Mouse
Clone: ABM2D48
Isotype: IgG2b, kappa
Immunogen: A partial length recombinant NALP3 protein (amino acids 150-385) was used as the immunogen for this antibody.
Application: WB, IHC

Description

Description: NALP3 (NACHT, LRR and PYD domains-containing protein 3), otherwise known as cryopyrin, is a member of the NLR (Nod-like-receptors) family. This is a pyrin-like protein, having N-terminal CARD or pyrin domains needed for homotypic protein protein interaction, an intermediate nucleotide binding self oligomerization NACHT domain and a C-terminal domain containing leucine rich repeats (LRRs). NALP3 is a key component of innate immunity and its expression is restricted to immune cells and chondrocytes. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kB signaling, and it plays an important role in the regulation of inflammation, the immune response, and apoptosis.

Additional Text

Gene Name

NLRP3

Gene ID

114548

Purification

Protein G purified

Uniprot ID

Q96P20

Antibody Clonality

Monoclonal

Application Notes

Western blot analysis: 6-8 µg/ml, Immunohistochemical analysis: 5 µg/ml

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.