Monoclonal Antibody to NALP3 (Clone: ABM2D48)
Catalogue Number: 10-3018-ABO
10-3018 Image
10-3018 Image
10-3018 Image
Fig-1: Western blot analysis of NALP3. Anti- NALP3 antibody (Clone: ABM2D48) was tested at 8 µg/ml on NIH 3T3 lysate.
10-3018 Image
Fig-2 : Immunohistochemical analysis of NALP3 in human spleen tissue using NALP3 antibody (Clone: ABM2D48) at 5 µg/ml.
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | NLRP3||C1orf7||CIAS1||NALP3||PYPAF1 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Mouse |
| Clone: | ABM2D48 |
| Isotype: | IgG2b, kappa |
| Immunogen: | A partial length recombinant NALP3 protein (amino acids 150-385) was used as the immunogen for this antibody. |
| Application: | WB, IHC |
Description
Description: NALP3 (NACHT, LRR and PYD domains-containing protein 3), otherwise known as cryopyrin, is a member of the NLR (Nod-like-receptors) family. This is a pyrin-like protein, having N-terminal CARD or pyrin domains needed for homotypic protein protein interaction, an intermediate nucleotide binding self oligomerization NACHT domain and a C-terminal domain containing leucine rich repeats (LRRs). NALP3 is a key component of innate immunity and its expression is restricted to immune cells and chondrocytes. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kB signaling, and it plays an important role in the regulation of inflammation, the immune response, and apoptosis.
Additional Text
Gene Name
NLRP3
Gene ID
114548
Purification
Protein G purified
Uniprot ID
Q96P20
Antibody Clonality
Monoclonal
Application Notes
Western blot analysis: 6-8 µg/ml, Immunohistochemical analysis: 5 µg/ml
Storage Note
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
10-3018 Datasheet
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