Monoclonal Antibody to TLR4 (Clone: HTA125)

Catalogue Number: 10-3021-ABO

Manufacturer:	Abeomics
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	TLR4
Shipping Condition:	Blue Ice
Storage Condition:	2-8°C
Unit(s):	100 ug, 25 ug
Host name:	Mouse
Clone:	HTA125
Isotype:	IgG2a, kappa
Immunogen:	This antibody was developed by immunizing mice with Ba/F3 cell line expressing human TLR4 cell surface antigen.
Application:	FACS

Overview
Datasheets

Description

Description: TLR4 (Toll-like receptor-4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It primarily mediates cellular signaling induced by Gram negative bacteria. TLR4 is highly specific for LPS and it is associated with CD14, a co-receptor for LPS. The downstream signaling pathway of TLR4 leads to the activation of NF-kappaB through myeloid differentiation protein (MyD88) and IL-1 receptor-associated kinase in various cell types. Keratinocytes express TLR4 at the mRNA and protein levels whereas TLR4 are also present in the normal human epidermis in vivo and their expression is regulated by microbial components. TLR4 is expressed on CD4+ T cells as well, the functional significance of which is unclear.

Additional Text

Gene Name

TLR4

Gene ID

7099

Purification

Protein G purified

Uniprot ID

O00206

Antibody Clonality

Monoclonal

Application Notes

FACS analysis: 2-4 µg/10^6

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

10-3021 Datasheet

Price

£260.00

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