Monoclonal Antibody to Mouse TLR9 (Clone: ABM4D70)

Catalogue Number: 10-3029-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Alias:TLR9
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 25 ug
Host name: Rat
Clone: ABM4D70
Isotype: IgG2a, kappa
Immunogen: A partial length recombinant mTLR9 protein (amino acids 602-860) was used as the immunogen for this antibody.
Application: FACS, WB

Description

Description: Mouse Toll-like receptor 9 (mTLR9) is an innate immune sensor for microbial DNA that erroneously responds to self DNA in autoimmune disease. TLR9 is normally expressed in endosomes/lysosomes where it is activated by pathogen-derived DNA. It has modulatory effect on the mucosal immune system, influence susceptibility to allergic sensitization to foods (22718261). TLR9 recognizes unmethylated CpG-containing DNA commonly found in bacteria. TLR9 signaling plays an important role in the development of robust protective immunity, proper recruitment and function of effector cells (lymphocytes and macrophages), and, ultimately, effective cryptococcal clearance from the infected lungs (20581055). It is involved in the pathogenesis of cardiovascular diseases, such as hypertension and heart failure.

Additional Text

Gene Name

TLR9

Purification

Protein G purified

Gene ID

81897

Uniprot ID

Q9EQU3

Antibody Clonality

Monoclonal

Application Notes

Western blot analysis: 2-4 µg/ml; FACS: 0.5-1 µg/10^6 cells

Storage Note

Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.