Monoclonal Antibody to Mouse TLR9 (Clone: ABM4D70)
Catalogue Number: 10-3029-ABO
10-3029 Image
10-3029 Image
10-3029 Image
Fig-2: Intracellular flow analysis of mTLR9 in mouse splenocytes using 0.5 µg/10^6 cells of mTLR9 antibody (Clone: ABM4D70). Green represents isotype control; red represents anti-mTLR9 antibody. Goat anti-Rat FITC conjugate was used as secondary.
10-3029 Image
Fig-1: Western blot analysis of mTLR9. Anti-mTLR9 antibody (Clone: ABM4D70) was tested at 2 µg/ml on mouse Small Intestine lysate.
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | TLR9 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Rat |
| Clone: | ABM4D70 |
| Isotype: | IgG2a, kappa |
| Immunogen: | A partial length recombinant mTLR9 protein (amino acids 602-860) was used as the immunogen for this antibody. |
| Application: | FACS, WB |
Description
Description: Mouse Toll-like receptor 9 (mTLR9) is an innate immune sensor for microbial DNA that erroneously responds to self DNA in autoimmune disease. TLR9 is normally expressed in endosomes/lysosomes where it is activated by pathogen-derived DNA. It has modulatory effect on the mucosal immune system, influence susceptibility to allergic sensitization to foods (22718261). TLR9 recognizes unmethylated CpG-containing DNA commonly found in bacteria. TLR9 signaling plays an important role in the development of robust protective immunity, proper recruitment and function of effector cells (lymphocytes and macrophages), and, ultimately, effective cryptococcal clearance from the infected lungs (20581055). It is involved in the pathogenesis of cardiovascular diseases, such as hypertension and heart failure.
Additional Text
Gene Name
TLR9
Purification
Protein G purified
Gene ID
81897
Uniprot ID
Q9EQU3
Antibody Clonality
Monoclonal
Application Notes
Western blot analysis: 2-4 µg/ml; FACS: 0.5-1 µg/10^6 cells
Storage Note
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
10-3029 Datasheet
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