Monoclonal Antibody to OPG (Clone: ABM10D2 )

Catalogue Number: 10-6001-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Alias:Tumor necrosis factor receptor superfamily member 11B|| Osteoclastogenesis inhibitory factor|| Osteoprotegerin
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 25 ug
Host name: Mouse
Clone: ABM10D2
Isotype: IgG1, kappa
Immunogen: A partial length recombinant protein (a.a 15-206) of OPG was used as the immunogen for this antibody.
Application: FACS, WB

Description

Description: OPG (Osteoprotegerin) belongs to the TNF receptor super-family and is implicated in bone remodeling and in the atherosclerotic process. This molecule acts as a decoy receptor for the RANKL (Receptor Activator of Nuclear Factor-KappaB Ligand), inhibiting binding of RANKL to its receptor, RANK. OPG acts as a soluble neutralizing receptor of TRAIL (TNF-Related Apoptosis-Inducing Ligand), an anti-inflammatory molecule with anti-atherosclerotic properties. Mostly implicated in bone remodeling, the RANK/RANKL/OPG axis is involved in immune and vascular system. OPG has been associated with increased risk of atherosclerotic disease in the general population. OPG has also been associated with increased pulse wave velocity, progression of arterial calcification and with mortality in both end-stage renal failure patients as well as the general population.

Additional Text

Gene Name

TNFRSF11B

Gene ID

4982

Purification

Protein G purified

Uniprot ID

O00300

Antibody Clonality

Monoclonal

Application Notes

WB: 4-6 µg/ml, FACS: 0.5-1 µg/10^6

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.