Monoclonal Antibody to TRF2 (Clone: ABM10H3)
Catalogue Number: 10-6002-ABO
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Fig-2 : Immunohistochemical analysis of TRF2 in human Breast tissue using TRF2 antibody (Clone: ABM10H3) at 5 µg/ml.
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Fig-3 : Immunohistochemical analysis of TRF2 in human Colon tissue using TRF2 antibody (Clone: ABM10H3) at 5 µg/ml.
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Fig-5 : Immunohistochemical analysis of TRF2 in Squamous cell carcinoma of Lungs using TRF2 antibody (Clone: ABM10H3) at 5 µg/ml.
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Fig-1: Western blot analysis of TRF2. Anti- TRF2 antibody (Clone: ABM10H3) was used at 2 µg/ml on Ramos and Raji lysates.
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Fig-4 : Immunohistochemical analysis of TRF2 in human Skin tissue using TRF2 antibody (Clone: ABM10H3) at 5 µg/ml.
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | TERF2||TRBF2||TRF2 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Mouse |
| Clone: | ABM10H3 |
| Isotype: | IgG1, kappa |
| Immunogen: | Full length recombinant TRF2 protein was used as the immunogen for this antibody. |
| Application: | WB, IHC |
Description
Description: TRF2 (Telomere Repeat Binding Factor 2), a subunit of the shelterin complex, binds to duplex telomeric DNA and plays a crucial role in telomere protection. TRF2 contains an N-terminal basic domain rich in glycines and arginines (the GAR domain), a central TRFH dimerization domain, a flexible linker region and a C-terminal Myb-like DNA binding domain. TRF2 undergoes extensive post-translational modification, which in turn regulates its stability, DNA binding and cellular localization. Ubiquitylation of TRF2 by Siah1, an E3 ligase, promotes TRF2 degradation and replicative senescence of human primary fibroblasts. TRF2 is phosphorylated in response to DNA damage and this phosphorylation has been implicated in DNA double strand break repair.
Additional Text
Gene Name
TERF2
Gene ID
7014
Purification
Protein G purified
Uniprot ID
Q15554
Antibody Clonality
Monoclonal
Application Notes
Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 5 µg/ml
Storage Note
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
10-6002 Datasheet
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