Monoclonal Antibody to DNMT3a (Clone: ABM1F35)
Catalogue Number: 10-7004-ABO
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | DNMT3A |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Mouse |
| Clone: | ABM1F35 |
| Isotype: | IgG1, kappa |
| Immunogen: | Full length recombinant DNMT3a protein was used as the immunogen for this antibody |
| Application: | WB |
Description
Description: Dnmt3a belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. Dnmt3a together with other methyltransferases conducts de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring. Dnmt3a also directs a metabolic program by repressing key genes to enable the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been found in several cancers including AML (Acute Myeloid Leukemia).
Additional Text
Gene Name
DNMT3A
Gene ID
1788
Purification
Protein G purified
Uniprot ID
Q9Y6K1
Antibody Clonality
Monoclonal
Application Notes
Western blot analysis: 2-4 µg/ml
Storage Note
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
10-7004 Datasheet
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