Monoclonal Antibody to DNMT3a (Clone: ABM1F35)

Catalogue Number: 10-7004-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Alias:DNMT3A
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 25 ug
Host name: Mouse
Clone: ABM1F35
Isotype: IgG1, kappa
Immunogen: Full length recombinant DNMT3a protein was used as the immunogen for this antibody
Application: WB

Description

Description: Dnmt3a belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. Dnmt3a together with other methyltransferases conducts de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring. Dnmt3a also directs a metabolic program by repressing key genes to enable the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been found in several cancers including AML (Acute Myeloid Leukemia).

Additional Text

Gene Name

DNMT3A

Gene ID

1788

Purification

Protein G purified

Uniprot ID

Q9Y6K1

Antibody Clonality

Monoclonal

Application Notes

Western blot analysis: 2-4 µg/ml

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.