Monoclonal Antibody to DNMT2 (Clone: ABM1H70)

Catalogue Number: 10-7010-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Alias:DNA (cytosine-5)-methyltransferase-like protein 2|| DNA methyltransferase homolog HsaIIP|| DNMT2
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 25 ug
Host name: Mouse
Clone: ABM1H70
Isotype: IgG1, kappa
Immunogen: A partial length recombinant protein from DNMT2 was used as the immunogen for this antibody.
Application: FACS, WB

Description

Description: DNMT2, also known as tRNA-aspartic acid methyltransferase 1 (TRDMT1), is highly conserved cytosine-C5 methyltransferase that introduces the C38 methylation of tRNAAsp in many species, including lower eukaryotes, plants, insects, and humans. DNMT2 contains all 10 sequence motifs that are conserved among m5C MTases, including the consensus S-adenosyl-L-methionine-binding motifs and the active site ProCys dipeptide. It is a relatively small protein of 391 amino acids and lacks the large N-terminal domains present in the DNMT1 and DNMT3 families. DNMT2 is ubiquitously expressed with multiple mRNA species in most human and mouse adult tissues. It is variably expressed in human cancer cell lines.

Additional Text

Uniprot ID

O14717

Gene Name

TRDMT1

Gene ID

1787

Purification

Protein G purified

Antibody Clonality

Monoclonal

Application Notes

WB: 4-6 µg/ml, FACS: 0.5-1 µg/10^6

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.