Mouse Monoclonal Antibody to Insulin Receptor (Clone: IR-1)
Catalogue Number: 10-7605-ABO
10-7605 Image
10-7605 Image
10-7605 Image
Fig 1: Cell surface staining of PBMC, lymphocytes gated. 1µg of antibody was used. Green Isotype control. Red Insulin Receptor antibody (Cat# 10-7605).
10-7605 Image
Fig 2: Cell surface staining of HepG2 cells. 2ug of antibody was used. Green Isotype control. Red Insulin Receptor antibody (Cat# 10-7605).
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | CD220|| HHF5|| HIR A|| INSR|| Insulin receptor|| Insulin receptor|| IR |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | IR-1 |
| Isotype: | |
| Immunogen: | |
| Application: | FACS |
Description
Description: The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular subunit and an extracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an auto-immune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.
Additional Text
Gene Name
INSR
Gene ID
3643
Purification
Protein G purified
Uniprot ID
P06213
Antibody Clonality
Monoclonal
Storage Note
Store at 2 to 8°C. For long term storage, store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
10-7605 Datasheet
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