Polyclonal Antibody to Vang like-1

Catalogue Number: 11-10013-ABO

Manufacturer:	Abeomics
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	VANGL1\|\|STB2
Shipping Condition:	Blue Ice
Storage Condition:	2-8°C
Unit(s):	100 ug, 25 ug
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	A partial length recombinant Vang like-1 protein (amino acids 148-400) was used as the immunogen for this antibody.
Application:	WB

Overview
Datasheets

Description

Description: Vangl1 (VANGL planar cell polarity protein 1) is an integral membrane protein that belongs to the tetraspanin family having four transmembrane domains. Tetraspanins form large multimolecular complexes on the cell membrane and are involved in cellular signaling, membrane formation, and migration. Vangl1 is expressed at the plasma membrane of different tissues and play a critical role in establishing planar cell polarity (PCP) in epithelial cells and are required for convergent extension (CE) movements during embryogenesis. It is a highly conserved and have evolved from a single ancestral protein Strabismus/Van Gogh found in Drosophila. Mutations in the vangl1 gene cause NTDs (neural tube defects). Ser/Thr phosphorylation of Vangl1 serves as an effector mediating the ITF healing response of the intestinal mucosa. In colon carcinoma cell lines, Vangl1 interacts with KAI1 (CD82) tumor metastasis suppressor. Vangl1 overexpression increases motility and metastasis, whereas its inhibition decreases motility and metastasis of colon cancer confirming migratory phenotype for Vangl1 in colonic epithelial cells.

Additional Text

Gene Name

VANGL1

Gene ID

81839

Uniprot ID

Q8TAA9

Purification

Protein A purified

Antibody Clonality

Polyclonal

Application Notes

Western blot analysis: 2-4 µg/ml

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

11-10013 Datasheet

Price

£242.00

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