Polyclonal Antibody to FNBP1

Catalogue Number: 11-10046-ABO

Manufacturer:	Abeomics
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	FBP17, KIAA0554
Shipping Condition:	Blue Ice
Storage Condition:	2-8°C
Unit(s):	100 ug, 25 ug
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	A partial length recombinant FNBP1 protein (amino acids 40-260) was used as the immunogen for this antibody.
Application:	WB

Overview
Datasheets

Description

Description: FNBP1 (formin binding protein 1) also known as FBP17,is an F-BAR domain protein that belongs to the formin-binding-protein family. It has a powerful self-polymerizing ability that promotes actin nucleation on membranes. F-BAR domain of FBP17 is capable of self-polymerizing into filaments, which adhere to the flat bilayer sheets and form a spiral protein coat around the tubulated membrane that they then induce. The gene for FNB1 maps to chromosome 9q34 and consists of a C-terminal Src homology 3 domain and an N-terminal region that is homologous to the cell division cycle protein, cdc15, a regulator of the actin cytoskeleton. The assembly of FBP17 is dependent on WASP, and its dissociation by WASP inhibition strongly induces a self-organization of PSTPIP2, another F-BAR protein, at podosomes. Podosomes/invadopodia are highly dynamic adhesive actin-based structures with enrichment of matrix metalloproteases (MMPs) activity formed at the ventral surface of the cell body, which are seen in macrophages, osteoclasts, dendritic cells and some cancer cells.

Additional Text

Gene Name

FNBP1

Uniprot ID

Q96RU3

Gene ID

23048

Purification

Protein A purified

Antibody Clonality

Polyclonal

Application Notes

Western blot analysis: 2-4 µg/ml

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

11-10046 Datasheet

Price

£242.00

-

Quantity
Unit Size

Find out about delivery