Polyclonal Antibody to Cbx5
Catalogue Number: 11-12012-ABO
| Manufacturer: | Abeomics |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | CBX5||HP1A |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Full length recombinant Cbx5 protein was used as the immunogen for this antibody. |
| Application: | WB |
Description
Description: Chromobox homolog 5 (Cbx5), lso known as HP1 is an evolutionarily conserved non-histone chromosomal protein involved in many biological progresses, such as heterochromatin formation, transcriptional regulation, DNA recombination and damage repair, RNA interference, kinetochore protein assembly, chromatin condensation and sister chromatid cohesion regulation. It binds lysine 9-methylated histone H3 (H3K9me), a hallmark of heterochromatin, and plays a crucial role in forming higher-order chromatin structures.Cbx5 has a conserved N-terminal chromo domain (CD), 3 a non-conserved hinge region, and a C-terminal chromo shadow domain. It localizes to centromeres in interphase through its CD domain, whereas mitotic centromeric localization depends on the CSD domain (CSD). Down regulation of Cbx5 has also been linked to the higher invasive potential of breast cancer cells.
Additional Text
Gene ID
23468
Gene Name
CBX5
Uniprot ID
P45973
Purification
Protein A purified
Antibody Clonality
Polyclonal
Application Notes
Western blot analysis: 1-2 µg/ml
Storage Note
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
11-12012 Datasheet
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