Coronavirus (COVID-19) Spike Protein Antibody

Catalogue Number: 11-2002-ABO

Manufacturer:	Abeomics
Type:	Polyclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 25 ug
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	A partial length recombinant coronavirus Spike Protein (amino acids 1100-1260) was used as the immunogen for this antibody.
Application:	ELISA, WB

Overview
Datasheets

Description

Description: The spike (S) protein of nCoV/SARS-CoV-2/COVID-19 is one of the structural glycoproteins that remains embedded in viral envelope and acts as the fundamental component of early viral infection of nCoV/SARS-CoV-2/COVID-19 upon binding the host receptor. The nCoV/SARS-CoV-2/COVID-19 has a trimeric spike protein which has two main domains such as S1 domain for receptor binding and S2 domain for membrane fusion and several specific cleavage sites in S1- S2 boundary junction that needs a novel, endocytic protease- primed cleavage to get activated during infection. It mainly binds to the furin protein on the cell membrane which performs trypsin like proteolytic cleavage and then the protein gets activated facilitating its entry into the host. This transmembrane spike protein of nCoV/SARS-CoV-2/COVID-19 shares binding property to the Angiotensin Converting Enzyme 2 (ACE2) likely to that of SARS- CoV. The high affinity of nCoV/SARS-CoV-2/COVID-19 Spike protein for human ACE2 may contribute to the apparent ease with which nCoV/SARS-CoV-2/COVID-19 can spread from human-to-human and make nCoV/SARS-CoV-2/COVID-19 pandemic.

Additional Text

Purification

Protein A purified

Antibody Clonality

Polyclonal

Application Notes

Recommended dilutions: WB: 2-4 µg/ml. However, this need to be optimized based on the research applications.

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

11-2002 Datasheet

Price

£242.00

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