Polyclonal ACE2 antibody

Catalogue Number: 11-2006-ABO

Manufacturer:	Abeomics
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	Angiotensin-converting enzyme homolog, Angiotensin-converting enzyme-related carboxypeptidase, Metalloprotease MPROT15
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 25 ug
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	A partial length recombinant ACE2 protein (amino acids 507-678) was used as the immunogen for this antibody.
Application:	ELISA, WB

Overview
Datasheets

Description

Description: Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.

Additional Text

Gene ID

59272

Uniprot ID

Q9BYF1

Gene Name

ACE2

Purification

Protein A purified

Antibody Clonality

Polyclonal

Application Notes

Recommended dilutions: WB: 05-1 µg/ml. However, this need to be optimized based on the research applications.

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

11-2006 Datasheet

Price

£242.00

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