Catalogue Number: 11-3024-ABO
Manufacturer: | Abeomics |
Type: | Polyclonal Primary Antibody - Unconjugated |
Alias: | NLRP3||C1orf7||CIAS1||NALP3||PYPAF1 |
Shipping Condition: | Blue Ice |
Storage Condition: | 2-8°C |
Unit(s): | 100 ug, 25 ug |
Host name: | Rabbit |
Clone: | |
Isotype: | IgG |
Immunogen: | A partial recombinant NALP3 protein (amino acids 1-200) was used as the immunogen for this antibody. |
Application: | WB |
Description: NALP3 (NACHT, LRR and PYD domains-containing protein 3), otherwise known as cryopyrin, is a member of the NLR (Nod-like-receptors) family. This is a pyrin-like protein, having N-terminal CARD or pyrin domains needed for homotypic protein-protein interaction, an intermediate nucleotide binding self-oligomerization NACHT domain and a C-terminal domain containing leucine-rich repeats (LRRs). NALP3 is a key component of innate immunity and its expression is restricted to immune cells and chondrocytes. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappa signaling, and it plays an important role in the regulation of inflammation, the immune response, and apoptosis.
NLRP3
114548
Q96P20
Protein A purified
Polyclonal
Western blot analysis: 2-4 µg/ml
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.