Polyclonal Antibody to HOIL-1L/RBCK1

Catalogue Number: 11-6007-ABO

Manufacturer:Abeomics
Type:Polyclonal Primary Antibody - Unconjugated
Alias:RBCK1||C20orf18||RNF54||UBCE7IP3||XAP3||XAP4
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 25 ug
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: A partial length recombinant HOIL-1L/RBCK1 protein (amino acids 121-333) was used as the immunogen for this antibody.
Application: WB

Description

Description: RBCK1 (RanBP-type and C3HC4-type zinc finger containing 1) is a transcription factor belonging to the RING-IBR protein family. It shuttles between the nucleus and cytoplasm, possessing both the nuclear export and localization signals within its amino acid sequence. RBCK1 deficiency causes polyglucosan storage myopathy associated with progressive muscle weakness and cardiomyopathy. RBCK1 negatively regulates the cellular antiviral response. RBCK1 regulates cell cycle progression and proliferation of ERalpha (estrogen receptor alpha)-positive breast cancer cells by supporting transcription of ERalpha and cyclin B1.

Additional Text

Gene Name

RBCK1

Uniprot ID

Q9BYM8

Gene ID

10616

Purification

Protein A purified

Antibody Clonality

Polyclonal

Application Notes

Western blot analysis: 2-4 µg/ml

Storage Note

Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.