Polyclonal Antibody to Histone H2A.x

Catalogue Number: 11-7010-ABO

Manufacturer:Abeomics
Type:Polyclonal Primary Antibody - Unconjugated
Alias:H2AFX||H2AX
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 25 ug
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: Full length recombinant Histone H2A.x protein was used as the immunogen for this antibody.
Application: WB

Description

Description: Histones are major chromatin proteins that wrap DNA to form nucleosome particles. Each nucleosome core particle consists of approximately 146 bp DNA wrapped by an octamer containing 2 molecules each of histones H2A, H2B, H3, and H4. Histone H1 sits on the linker DNA between nucleosomes. Their major function is to compact long DNA strands inside the nucleus and chromatin regulation. Histone H2A X is a 15 kDa variant of Histone H2. Histone H2A X is also required for the repair of double-stranded DNA breaks particularly when modified by C-terminal phosphorylation on Ser-140. Histone H2A X is expressed in all eukaryotic cells.

Additional Text

Gene ID

3014

Uniprot ID

P16104

Purification

Protein A purified

Gene Name

H2ax

Antibody Clonality

Polyclonal

Application Notes

Western blot analysis: 2-4 µg/ml

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.