Recombinant Mouse Monoclonal Antibody to ACTH (Adrenocorticotrophic Hormone) (N-Terminal) (Pituitary Marker)(Clone : r57)

Catalogue Number: 12-1010-ABO

Manufacturer:	Abeomics
Type:	Recombinant Monoclonal
Alias:	Adrenocorticotropin, alpha or beta or gamma Melanocyte Stimulating Hormone (MSH) or Melanotropin, beta-Endorphin, beta or gamma Lipotropin (LPH), CLIP, Met Enkephalin, POC, POMC
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug
Host name:
Clone:	r57
Isotype:	IgG1, kappa
Immunogen:	N-terminal fragment of human ACTH conjugated to KLH
Application:	ELISA, IHC

Overview
Datasheets

Description

Description: ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

Additional Text

Gene Name

POMC

Gene ID

5443

Uniprot ID

P01189

Purification

Purified

Antibody Clonality

Monoclonal

Application Notes

ELISA (For coating, order Ab without BSA); ,Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)

Storage Note

Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

12-1010 Datasheet

Price

£533.00

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