Anti-Bcl-6 (Follicular Lymphoma Marker) Recombinant Mouse Monoclonal Antibody (Clone:rBCL6/1527)
Catalogue Number: 12-1080-ABO
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Figure 1: Formalin-fixed, paraffin-embedded human Hodgkin's Lymphoma stained with BCL-6 Mouse Recombinant Monoclonal Antibody (rBCL6/1527).
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Figure 2: SDS-PAGE Analysis of Purified BCL-6 Mouse Recombinant Monoclonal Antibody (rBCL6/1527).
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| Manufacturer: | Abeomics |
| Shelf Life: | 24 months |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 20 ug |
| Host name: | Mouse |
| Clone: | rBCL6/1527 |
| Isotype: | |
| Immunogen: | Recombinant fragment of human bcl-6 protein (around aa 256-389) (exact sequence is proprietary) |
Description
Description: The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ( L&H ) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Additional Text
Gene ID
604
Gene Name
BCL6
Uniprot ID
P41182
Purification
Protein A/G Purified
Specificity
B-cell lymphoma 5 protein; B-Cell Lymphoma 6 Protein; BCL5; BCL6; BCL6A; cys his2 zinc finger transcription factor; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor
Antibody Clonality
Monoclonal
Storage Note
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
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