Anti-Thrombomodulin / CD141 (Endothelial Cell Marker) Recombinant Mouse Monoclonal Antibody (Clone:rTHBD/1591)
Catalogue Number: 12-1247-ABO
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Figure 1: Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with Thrombomodulin / CD141 Monoclonal Antibody (rTHBD/1591).
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Figure 2: Formalin-fixed, paraffin-embedded human Placenta stained with Thrombomodulin / CD141 Monoclonal Antibody (rTHBD/1591).
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Figure 3:SDS-PAGE Analysis Purified Thrombomodulin Mouse Recombinant Monoclonal Antibody (rTHBD/1591).
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| Manufacturer: | Abeomics |
| Shelf Life: | 24 months |
| Type: | Recombinant Monoclonal |
| Alias: | AHUS6; BDCA3; CD141; Fetomodulin; Thbd; THPH12; THRM; Thrombomodulin (TM) |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 20 ug |
| Host name: | Mouse |
| Clone: | rTHBD/1591 |
| Isotype: | IgG1, kappa |
| Immunogen: | Recombinant fragment of human Thrombomodulin protein (around aa 69-194) (exact sequence is proprietary) |
| Application: | ELISA, IHC |
Description
Description: It recognizes a protein of 75kDa, identified as Thrombomodulin. Thrombomodulin is a transmembrane glycoprotein with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytio-trophoblasts of placenta also express thrombomodulin. This protein is present in almost all of benign vascular tumors and majority of malignant vascular tumors (Kaposi s sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. Recently, thrombomodulin antibody has been used for mesothelial cells and malignant mesotheliomas.
Additional Text
Gene ID
7056
Gene Name
THBD
Uniprot ID
P07204
Purification
Protein A/G Purified
Antibody Clonality
Monoclonal
Application Notes
ELISA (Use Ab at 2-4µg/ml for coating) (Order Ab without BSA); Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10mM Tris buffer with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Storage Note
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
12-1247 Datasheet
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