Anti-TTF-1 / NKX2.1 (Thyroid & Lung Epithelial Marker) Recombinant Mouse Monoclonal Antibody (Clone:rNX2.1/690)
Catalogue Number: 12-1259-ABO
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Figure 1: Formalin-fixed, paraffin-embedded human Lung Adenocarcinoma stained with TTF-1 Mouse Recombinant Monoclonal Antibody (rNX2.1/690).
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Figure 2: Formalin-fixed, paraffin-embedded human Thyroid stained with TTF-1 Mouse Recombinant Monoclonal Antibody (rNX2.1/690).
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Figure 3:SDS-PAGE Analysis Purified TTF-1 Mouse Recombinant Monoclonal Antibody (rNX2.1/690).
| Manufacturer: | Abeomics |
| Shelf Life: | 24 months |
| Type: | Recombinant Monoclonal |
| Alias: | BCH, Benign chorea, BHC, Homeobox protein Nkx2.1, NK2 homeobox 1, NKX2.1, NKX2A, TEBP, Thyroid nuclear factor-1, Thyroid specific enhancer binding protein, Thyroid transcription factor-1 (TTF-1), Tin man, TITF1, TTF-1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 20 ug |
| Host name: | Mouse |
| Clone: | rNX2.1/690 |
| Isotype: | IgG1, kappa |
| Immunogen: | Recombinant full-length TTF-1 protein |
| Application: | IHC |
Description
Description: Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
Additional Text
Gene ID
7080
Gene Name
NKX2-1
Purification
Protein A/G Purified
Uniprot ID
P43699
Antibody Clonality
Monoclonal
Application Notes
Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Storage Note
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
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