Phospho-NFKB p65 (Ser536) (Clone: B7) rabbit mAb PE conjugate

Catalogue Number: 12-4308-ABO

Manufacturer:	Abeomics
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA, NFKB3
Shipping Condition:	Blue Ice
Unit(s):	10 tests, 100 tests
Host name:	Rabbit
Clone:	NFKBp65S536-B7
Isotype:	IgG1, kappa
Immunogen:	A synthetic phospho-peptide corresponding to residues surrounding Ser536 of human phospho-NFKB p65
Application:	FACS

Overview
Datasheets

Description

Description: The nuclear factor kB (NFkB)/Rel family of transcription factors play a pivotal role in inflammatory and immune responses (1,2). NF-kappa-B is present in almost all cell types and is involved in many biological processes including immunity, inflammation, cell growth and differentiation, apoptosis, and tumorigenesis. NFkB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFkB1/p105, NFkB1/p50, REL and NFkB2/p52. The dimers bind at kB sites in the target gene DNA. Individual dimers have distinct preferences for different kB sites and can act as either transcriptional activators or repressors. NFkB Ser536 phosphorylation stimulates Lys310 acetylation and interaction of phospho NFkB with CBP. Acetylated/phospho NFkB induces enhanced transcriptional activity.

Additional Text

Antibody Clonality

Monoclonal

Application Notes

For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.

Storage Note

Store at 2-8°C. Avoid repeated freeze and thaw cycles.

12-4308 Datasheet

Price

£403.00

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