Phospho-MCM2 (Ser139) (Clone: B12) rabbit mAb

Catalogue Number: 12-4329-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Alias:DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28, CCNL1, CDCL1, KIAA0030
Shipping Condition:Blue Ice
Unit(s): 20 ul, 200 ul
Host name: Rabbit
Clone: MCM2S139-B12
Isotype: IgG1, kappa
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho MCM2
Application: FACS, WB

Description

Description: The members of minichromosome maintenance (McM) protein family 2-7 were originally identified as a group of proteins essential for DNA replication (chromosomal maintenance (1,2). They share common sequence homology to each other in their nulceotide-binding domains and are distinct subgroup of the large AAA ATPase family, which are required for the initiation and elongation of DNA replication. It has been reported that Cdc7/Dbf4 phospohrylates MCM2 during G1/S cell cycle which coincides with the intiation of DNA replication (3,4)

Additional Text

Antibody Clonality

Monoclonal

Application Notes

1µg/mL - 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.(0.5mg/ml, more than 200 western blots)

Storage Note

Store at -20°C. Avoid repeated freeze and thaw cycles.