Anti-Human CD194 (CCR4) (Mogamulizumab)-Biotin

Catalogue Number: 12-8020-ABO

Manufacturer:	Abeomics
Type:	Recombinant Monoclonal
Alias:	CD194; CKR-4; CCR-4; CCR4; K5-5
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Human
Clone:	KW-0761
Isotype:	IgG1, kappa
Immunogen:	Humanization of mouse anti-CCR4 mAb7.
Application:	ELISA

Overview
Datasheets

Description

Description: Expression Host : HEK-293 This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Mogamulizumab. Clone KW-0761 recognizes human CD194 (CCR4). This product is for research use only. Clone KW-0761 (Mogamulizumab) is a research-grade, afucosylated, humanized monoclonal antibody generated from mouse anti-CCR4 mAb7 that targets human CCR4.1 CC chemokine receptor type 4 (CCR4) is a protein that belongs to the G protein-coupled receptor family and is a receptor for a variety of CC chemokines including MCP-1, MIP-1, RANTES, TARC, and Macrophage-derived chemokine. Chemokines are involved in the development, homeostasis, and function of the immune system and are known to regulate cell trafficking of various types of leukocytes. In a 2018 Phase I clinical trial, Mogamulizumab was found to decrease the number of HTLV-1-0;infected cells and the levels of inflammatory markers related to HTLV-1-0;Associated Myelopathy.3

Additional Text

Antibody Clonality

Monoclonal

Application Notes

The suggested concentration for Mogamulizumab biosimilar antibody for staining cells in flow cytometry is <= 1.0 µg per 106 cells in a volume of 100 µl. Titration of the reagent is recommended for optimal performance for each application.ELISA

Storage Note

Functional grade biosimilar antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

12-8020 Datasheet

Price

£614.00

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Quantity
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