Recombinant anti-human-IL-1 beta Antibody (Canakinumab Biosimilar)

Catalogue Number: 12-9112-ABO

Manufacturer:Abeomics
Type:Recombinant Monoclonal
Alias:Interleukin-1 beta, Catabolin
Shipping Condition:Blue Ice
Unit(s): 100 ug
Host name:
Clone:
Isotype: IgG1
Immunogen:
Application: ELISA, FACS, ICC, IF, FA

Description

Description: Target: IL-1 Beta Generic name: Canakinumab Product Origin: Recombinant in Human cells Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass with a molecular mass of 145157 Daltons when deglycosylated. Canakinumab binds to human IL-1β and neutralizes its inflammatory activity by blocking its interaction with IL-1 receptors, but it does not bind IL-1alpha or IL-1 receptor antagonist (IL-1ra). References: 1. Church LD, McDermott MF: Canakinumab, a fully-human mAb against IL-1beta for the potential treatment of inflammatory disorders. Curr Opin Mol Ther. 2009 Feb;11(1):81-89. 2. Lachmann HJ, et al.: Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med. 2009 Jun 4;360(23):2416-25. doi:10.1056/NEJMoa0810787

Additional Text

Gene Name

IL1B

Gene ID

3553

Uniprot ID

P01584

Purification

Affinity Purified

Antibody Clonality

Monoclonal

Application Notes

Specificity: Human IL1 beta. Does not cross react with other members of the interleukin-1 family. Inquire for more than 1 mg quantities.