Recombinant anti-human-IL-1 beta Antibody (Canakinumab Biosimilar)
Catalogue Number: 12-9112-ABO
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12-9112 Image
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Figure 1. ELISA plate pre-coated by 1 µg/mL (100 µL/well) Human IL1B Protein, hFc Tag (Abeomics 32-17198) can bind Anti-IL1B Neutralizing antibody (Abeomics 12-9112) in a linear range of 0.61-156.25 ng/mL.
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Figure 2. Flow cytometry analysis with 1 µg/mL Anti-IL1B (canakinumab biosimilar) mAb (Abeomics 12-9112) on Expi293 cells transfected with Human IL1B protein (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
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Fig. 3: Coomassie staining of SDS-PAGE gel loaded with Anti-IL-1beta (Canakinumab biosimilar) mAb.
| Manufacturer: | Abeomics |
| Type: | Recombinant Monoclonal |
| Alias: | Interleukin-1 beta, Catabolin |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | |
| Clone: | |
| Isotype: | IgG1 |
| Immunogen: | |
| Application: | ELISA, FACS, ICC, IF, FA |
Description
Description: Target: IL-1 Beta Generic name: Canakinumab Product Origin: Recombinant in Human cells Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass with a molecular mass of 145157 Daltons when deglycosylated. Canakinumab binds to human IL-1β and neutralizes its inflammatory activity by blocking its interaction with IL-1 receptors, but it does not bind IL-1alpha or IL-1 receptor antagonist (IL-1ra). References: 1. Church LD, McDermott MF: Canakinumab, a fully-human mAb against IL-1beta for the potential treatment of inflammatory disorders. Curr Opin Mol Ther. 2009 Feb;11(1):81-89. 2. Lachmann HJ, et al.: Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med. 2009 Jun 4;360(23):2416-25. doi:10.1056/NEJMoa0810787
Additional Text
Gene Name
IL1B
Gene ID
3553
Uniprot ID
P01584
Purification
Affinity Purified
Antibody Clonality
Monoclonal
Application Notes
Specificity: Human IL1 beta. Does not cross react with other members of the interleukin-1 family. Inquire for more than 1 mg quantities.
12-9112 Datasheet
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