Danoprevir
Catalogue Number: 15-4004-ABO
| Manufacturer: | Abeomics |
| Shelf Life: | 24 months |
| Type: | Protease Inhibitors |
| Alias: | ITMN-191, R-7227 |
| Shipping Condition: | Dry Ice |
| Unit(s): | 5 mg, 1 mg |
Description
Description: Molecular Formula: C35H46FN5O9S Molecular Weight: 731.8 Danoprevir is an orally bioavailable inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A; IC50 = 1 nM), a serine protease essential for HCV replication.It is selective for NS3/4A over a panel of 53 proteases at a concentration of 10 µM. Danoprevir inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s = 0.2-0.4 nM) as well as 2b and 3a (IC50s = 1.6 and 3.5 nM, respectively) in vitro. It also reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC50 = 1.8 nM).
Additional Text
Application Notes
A stock solution may be made by dissolving the danoprevir in the solvent of choice. Danoprevir is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of danoprevir in these solvents is approximately 15, 25, and 30 mg/ml, respectively. Danoprevir is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, danoprevir should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Danoprevir has a solubility of approximately 0.2 mg/ml in a 1:4 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Storage Note
Store at -20°C, product is stable for at least two years.
15-4004 Datasheet
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