Alpha 2 Macroglobulin, Fast Form, Human Plasma
Catalogue Number: 16-16-012013-FF-ART
16-16-012013-FF Image
16-16-012013-FF Image
SDS-PAGE: 4-20% Novex Tris-Glycine Gel (Invitrogen, Catalog # EC6025BOX) with 1X Tris-glycine running buffer 1. Alpha 2 Macroglobulin - 2 µg (no heat/reduced) 2. Alpha 2 Macroglobulin - 4 µg (no heat/reduced) 3. Alpha 2 Macroglobulin - 8 µg (no heat/reduced) 4. Alpha 2 Macroglobulin - 10 µg (no heat/reduced) 5. Empty 6. ProSieve Color ProteinMarkers Lonza, Catalog # 50550 7. Alpha 2 Macroglobulin - 2 µg (heated/reduced) 8. Alpha 2 Macroglobulin - 4 µg (heated/reduced) 9. Alpha 2 Macroglobulin - 8 µg (heated/reduced) 10. Alpha 2 Macroglobulin - 10 µg (heated/reduced)
| Manufacturer: | Athens Research |
| Preservative: | Lyophilized from 100 mM Na Phosphate, pH 7.2 |
| Molecular Weight: | 725000 |
| Ph: | pH 7.2 |
| Physical state: | Lyophilized |
| Type: | Protease Inhibitor Protein |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 500 ug |
Description
Description: Alpha 2 Macroglobulin (A2M) is a plasma protease inhibitor which has been shown to exist in two forms. The Slow Form of A2M (S-A2M) is the form which possesses the ability to bind and inhibit proteases by a "trap" method. The Fast Form of A2M (F-A2M) is generated when S-A2M undergoes a conformational change due to either entrapment of a protease in the A2M bait region, or chemical cleaveage of an internal thiol ester bond located near the bait region. F-A2M does not possess the ability to bind and inhibit protease activity. F-A2M is rapidly taken up by the liver, with a half life of 2-4 minutes. In vivo, F-A2M typically represents only 0.17-0.7% of the total A2M in blood plasma of adults. The F-A2M plasma concentration is, however, increased in many disease states including pancreatitis, multiple sclerosis and sepsis. F-A2M has also been implicated in the inhibition of amyloid formation associated with Alzheimer's disease and spongiform encephalopathies.
16-16-012013-FF Datasheet
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