C-Reactive Protein, Human Plasma
Catalogue Number: 16-16-031816-ART
| Manufacturer: | Athens Research |
| Preservative: | Frozen in 20mM Tris, pH 8.0, with 280 mM NaCl, 5mM CaCl2, and 0.05% NaN3 |
| Molecular Weight: | 24,000 Da |
| Ph: | pH 8.0 |
| Physical state: | Frozen |
| Type: | Cell Cycle Proteins |
| Shipping Condition: | Dry Ice |
| Storage Condition: | -70°C |
| Unit(s): | 1 mg, 100 ug |
Description
Description: C-Reactive Protein (CRP) is a homopentameric protein with a monomer size of ~24 kDa. It is a member of the pentraxin family, a family of proteins characterized by their calcium dependent ligand binding and unique ring-like structure. Like many other pentraxins, CRP is highly upregulated in the acute-phase response to bodily insults such as tissue injuries, infections and general inflammation. In normal, healthy individuals the concentration of CRP in blood is ~5 mg/ml. This number rises 5-10 fold in response to infection or other causes of inflammation. In severe cases, CRP levels can rise above 200 mg/L. CRP can be used as a biomarker for general inflammation or more specific issues such as certain cancers, diabetes, hypertension, cardiovascular disease (CVD) or Rheumatoid Arthritis (RA). On a cellular/molecular level, CRP activates the complement system of the immune response by binding to surface molecules on dead/dying cells or foreign/invading bacteria.
16-16-031816 Datasheet
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