Haptoglobin, Human Plasma
Catalogue Number: 16-16-080116-ART
| Manufacturer: | Athens Research |
| Preservative: | Salt-free lyophilized solid. |
| Molecular Weight: | Hp 1-1: 86,000; Hp 2-1: 200,000; Hp 2-2: 400,000 |
| Physical state: | Lyophilized |
| Type: | Glycoproteins |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 5 mg |
Description
Description: An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes: Hp 1-1, Hp 2-1, and Hp 2-2. While the phenotypic distribution can vary greatly between ethnicities and geographic location, the Hp 2-1 phenotype is the most prevalent phenotype in humans. Plasma concentrations of haptoglobin are highest in individuals with Hp 1-1, intermediate in Hp 2-1 individuals, and lowest in Hp 2-2 individuals. Hp 1-1 is the most effective at binding hemoglobin, and Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype.
16-16-080116 Datasheet
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