Capitainer®B Vanadate, 50 pcs box CE/IVD
Catalogue Number: 210-0052-CTR
| Manufacturer: | Capitainer |
| Type: | Dried Blood Spot |
| Shipping Condition: | RT |
| Storage Condition: | RT |
| Unit(s): | 50 Pieces |
| Range: | |
| Sensitivity: | Reproducibility: Better than 0.5 μl as one Standard Deviation (SD), (CV <5%) Outliers: Rate of over- or under-sampling (with a deviation >3 SD) <0.1% Non-sampling: <5% |
| Sample type: | |
| Sample size: |
Description
Description:
Patent pending PCT/EP2021/068386
Capitainer®B Vanadate is based on the technology of Capitainer® B. In addition, it incorporates our proprietary technology for integrating the phospholipase D (PLD) inhibitor sodium metavanadate (NaVO3) in the DBS paper disc.
Enables accurate testing of Phosphatidylethanol (PEth)
Eliminates the risk of post sampling PEth formation
Shipping and storage of the sample in ambient temperature
Volumetric, solves the problem with traditional DBS
Enables easier sampling via finger blood
Capitainer® B Vanadate is the only volumetric microsampling device scientifically shown to enable accurate PEth testing without risk of post sampling formation [1].
About phosphatidylethanol (PEth)
PEth is found in red blood cells and is an abnormal phospholipid that is formed in the presence of ethanol. It is formed via a transphosphatidylation reaction of phospholipase D (PLD). PEth accumulates with frequent alcohol consumption with a half-life of approximately 4 days and is therefore a marker for long term alcohol use.
In blood that contains ethanol at sampling, PEth may continue to form after sampling [2] leading to falsely elevated concentrations. A well-known problem in venous blood samples were storage temperature and shipping conditions need to be controlled to limitit In Vitro formation. Formation of PEth can be stopped through inhibiting the PLD activity. Sodium metavanadate (NaVO3) is an effective PLD inhibitor.
We recommend reading the full publication of Beck et al. [1] for more details regarding the advantages with Capitainer® B Vanadate in PEth analysis.
Beck, O., Mellring, M., Löwbeer, C. et al. Measurement of the alcohol biomarker phosphatidylethanol (PEth) in dried blood spots and venous blood—importance of inhibition of post-sampling formation from ethanol. Anal Bioanal Chem 413, 5601–5606 (2021).
Schröck A, Henzi A, Bütikofer P, König S, Weinmann W. Determination of the formation rate of phosphatidylethanol by phospholipase D (PLD) in blood and test of two selective PLD inhibitors. Alcohol. 2018 Dec;73:1-7.
210-0052 Datasheet
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