Catalogue Number: 27263-IBL
Manufacturer: | IBL - (Immuno-Biologicals Laboratories Co Ltd) |
Type: | Human ELISA Kit |
Shipping Condition: | Blue Ice |
Storage Condition: | 2-8°C |
Unit(s): | 96 well plate |
Range: | 0.13 ~ 8 ng/mL |
Sensitivity: | |
Sample type: | Plasma, Serum |
Sample size: |
Description: Endothelial Lipase (EL) is a metabolic enzyme of HDL. It is phospholipase A1 molecule that is high substrate specificity against to phospholipid that exists in high density lipoprotein, HDL molecule and it promotes HDL metabolism through metabolizing HDL phospholipid. It has been considered that EL involves with lipid metabolism and elevating risk of arteriosclerosis as strong expression of EL on newly formed vessel, macrophage in arteriosclerotic lesions is observed while EL expresses in vascular endothelial cells and vascular smooth myocytes of normal blood vessels. It has been reported that both full length EL (active form) and cleaved EL (inactive forms, 40K fragment cleaved at N terminal and 28K fragment cleaved at C terminal cleaved by proprotein convertase) exist in blood. This ELISA kit is designed using two antibodies that detects C terminal fragments that can detect both full length EL and cleaved form EL that is cleaved at C-terminal in serum and EDTA-plasma regardless with or without administration of heparin injection that is conventionally required for the measurement. Keywords: Lipase / Lipid Metabolism / Dyslipidemia