Mouse/Rat sAPP (highly sensitive) Assay Kit 27419
Catalogue Number: 27419-IBL
| Manufacturer: | IBL - (Immuno-Biologicals Laboratories Co Ltd) |
| Type: | Rodent ELISA kit |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 96 well plate |
| Range: | 4.1 ~ 260 pg/mL |
| Sensitivity: | |
| Sample type: | Cell Culture Supernatant, Plasma, Serum |
| Sample size: |
Description
Description: Alzheimer's disease (AD) was first reported by A. Alzheimer, a German neuropathologist in 1907 and is considered as a major factor of dementia. It is known that Amyloid β (Aβ; which is major constituent of senile plaque) is cleaved from Amyloid Precursor Protein (APP; which exists in three main isoforms, APP695, APP751, and APP770) by β-secretase and subsequent γ-secretase. The production of soluble APPβ (sAPPβ) by β-secretase cleavage corresponds to Aβ production accordingly, so it is desired to measure sAPPβ in parallel with Aβ. On the other hand, it is considered that in the metabolic pathway of APP, APP is first cleaved by α-secretase rather than β-secretase normally to produce soluble APPα (sAPPα) and subsequently P3 is cleaved from the remaining C-terminal fragment by γ-secretase. In recent research, there are several attempts to apply the inhibitor of β-secretase and the activation of α-secretase for AD treatment. As stated above, it is useful for research of AD to measure sAPPα as well as sAPPβ. This kit can measure Mouse/Rat sAPPα. Note: Please pay attention in sample selection since this kit also measures full-length APP.
27419 Datasheet
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