Mouse/Rat Total Insulin (high sensitivity) Assay Kit 27705
Catalogue Number: 27705-IBL
| Manufacturer: | IBL - (Immuno-Biologicals Laboratories Co Ltd) |
| Type: | Rodent ELISA kit |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 96 well plate |
| Range: | 1.25 ~ 80 pg/mL |
| Sensitivity: | |
| Sample type: | Plasma, Serum |
| Sample size: |
Description
Description: Insulin is peptide hormone that is released from the beta cells of the islets of Langerhans of pancreas. It is synthesized as 86 amino-acid precursor "proinsulin" and it is cleaved by C-peptide and insulin that consists of 21 amino-acid A-chain and 30 amino-acid β chain that is linked by disulfide binding due to activation of prohormone conversion enzyme (PC2, PC3) in secretory granule. Insulin deposits glucose and promotes synthesize protein in skeletal muscles. It also has physiological function such as suppress gluconeogenesis in liver and it has been known as an only hormone that can decrease blood glucose. Insulin is constantly released to maintaining the level of blood glucose while it is also released in large amount stimulated by incretin and glucose for suppressing rapidly increased blood glucose after meal. However, lack of insulin secretion and decreasing insulin sensitivity are observed and eventually high blood glucose is observed in diabetic conditions. Measuring insulin in fasting (F-IRI) is required for clinical assessment of diabetes such as function of insulin secretion and insulin resistance. This ELISA kit can measure mouse and rat total insulin including proinsulin and low concentration of insulin in fasting using tiny amount of samples. The control set is available for sale on request. Keywords: GIP / GLP-1 / Insulin / Incretin
27705 Datasheet
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