Mouse/Rat Intact Proinsulin CLEIA Kit 27708

Catalogue Number: 27708-IBL

Manufacturer:	IBL - (Immuno-Biologicals Laboratories Co Ltd)
Type:	CLIA
Shipping Condition:	Blue Ice
Storage Condition:	2-8°C
Unit(s):	96 well plate

Overview
Datasheets

Description

Description: Proinsulin is a precursor of insulin that is synthesized in the β cells of the islet of Langerhans of pancreas. Most of the proinsulin synthesized in the rough endoplasmic reticulum of β cells is stored in the secretory granules. It is cleaved by prohormone converting enzyme (PC 2 and PC 3) and it is divided into insulin that consists of 21 amino-acid A chain and 30 amino-acid B chain and C-peptide that consists of 33 amino acid, then it is released in blood by secretory stimulation such as glucose. However, some proinsulin does not enter secretory granules and it is subsequently released in blood as intact (full length) proinsulin without the processing. It has been known that the ratio of proinsulin and insulin (P/I ratio) is an indicator of dysfunction of pancreatic β cell as the ratio of proinsulin become higher due to abnormality of the processing caused by dysfunction of pancreatic β cell. It has been suggested that the P/I ratio is a valuable pancreatic β cell evaluation method that does not require a loading test as it can be measured using blood samples in fasting. This CLEIA kit has a wide measurement range to measure the intact proinsulin at low level in fasting and at high level after loading using only 10 µL sample.

27708 Datasheet

Price

£591.00

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