Mouse/Rat Amyloidβ (1-42) Assay Kit 27721

Catalogue Number: 27721-IBL

Manufacturer:	IBL - (Immuno-Biologicals Laboratories Co Ltd)
Type:	Rodent ELISA kit
Shipping Condition:	Blue Ice
Storage Condition:	2-8°C
Unit(s):	96 well plate
Range:	1.56 ~ 100 pg/mL
Sensitivity:
Sample type:	Plasma, Serum
Sample size:

Overview
Datasheets

Description

Description: The first case of Alzheimer's disease was defined and reported in 1907 by the German scientist, Dr. A. Alzheimer. His studies have shown that this is the main cause of dementia in the elderly. The plaques which appear in the brains of individuals who suffers AD are mostly constituted by the Amyloidβ protein (Aβ). Aβ is a peptide which consists of 40 or 42 (43) amino acids, and reports show that this is cleaved from β- and γ- secretase from the amyloid precursor protein. APP is a trans-membrane protein consisting of 695, 751, or 770 amino acids. Reports have shown many variants of Aβ exist and are clarified into the culture supernatant from the APP cDNA transfected mouse neuroblastoma cell. Furthermore, in 1995, a dominant and differential deposition of distinct βamyloid peptide species, Aβ (N3pE), in senile plaques was found by Saido et al. This modified molecule, starting at the 3rd amino terminal residue, glutamate, was discovered to convert to pyroglutamate through intramolecular dehydration . This product is useful for measuring Aβ42 in blood sample (serum or plasma) of mouse or rat. Since this product hardly cross-reacts with human Aβ, it is useful for the measurement of mouse and rat Aβ42, when human Aβ is intermingled with the measurement sample. The control set is available for sale on request. Keywords: Alzheimer's Disease / Amyloid β / Amyloid-β / Amyloid Beta / Aβ / Beta Amyloid

27721 Datasheet

Price

£515.00

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