Human APP βCTF Assay Kit 27776
Catalogue Number: 27776-IBL
| Manufacturer: | IBL - (Immuno-Biologicals Laboratories Co Ltd) |
| Type: | Human ELISA Kit |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 96 well plate |
| Range: | 0.19 ~ 12 pmol/L |
| Sensitivity: | |
| Sample type: | Cell Extract |
| Sample size: |
Description
Description: Alzheimer's disease (AD) was first reported by A. Alzheimer, a German neuropathologist in 1907 and is considered as a major factor of senile dementia. It is known that Amyloid β (Aβ; which is a major constituent of senile plaque) is cleaved from Amyloid Precursor Protein (APP; which exists in three main isoforms, APP695, APP751, and APP770) by β-secretase and subsequent γ-secretase. On the one hand, it has been also reported there is βCTF (β-secretase C-terminal fragment), fragments which are cleaved by β-secretase but not by γ-secretase. It is thought that measuring βCTF, in addition to Aβ, soluble APPα and APPβ, also has significance in research of the metabolic pathway of APP. This ELISA can measure human APP βCTF in samples such as cultured cell lysate. The control set is available for sale on request.
27776 Datasheet
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