soluble (Pro)renin Receptor Assay Kit 27782
Catalogue Number: 27782-IBL
| Manufacturer: | IBL - (Immuno-Biologicals Laboratories Co Ltd) |
| Type: | Other ELISA Kits |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 96 well plate |
| Range: | 125 ~ 8,000 pg/mL |
| Sensitivity: | |
| Sample type: | Cell Culture Supernatant, Plasma, Serum, Urine |
| Sample size: |
Description
Description: (Pro)renin receptor/(P)RR is a common receptor protein between renin and prorenin. When prorenin binds to (P)RR, it achieves a binding ability to angiotensinogen and gains a catalytic activity for conversion from angiotensinogen to ansiotensin I in comparable level with renin. Additionally, when the (P)RR is stimulated by binding to prorenin, its intracellular signaling progresses. Through this, (P)RR research is believed to have an important implication in building of new strategy for suppressing of overactivated tissue RAA (Renin-Angiotensin-Aldosterone) system. (P)RR is a 39 kDa, single transmembrane receptor protein and it is reported that 29 kDa soluble form is generated by cleavage of (P)RR with furin. Thus the quantitative assay of soluble (P)RR in blood or urine samples is expected to provide new knowledges to clarification of disease mechanisms and development of new tools for diseases. This ELISA kit can measure concentration of human soluble (pro)renin receptor in blood or urein samples.
27782 Datasheet
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