Anti-GRAP2/GADS Monoclonal Antibody (Clone:UW40)

Catalogue Number: 30-1448-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Alias:GRAP2||GADS||GRB2L||GRID
Shipping Condition:Blue Ice
Unit(s): 0.1 mg
Host name: Mouse
Clone: UW40
Isotype: IgG2a
Immunogen: GST-fusion human GRAP2/GADS protein
Application: FACS, IP, WB

Description

Description: GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.

Additional Text

Gene ID

9402

Gene Name

GRAP2

Storage Note

Store at 2-8°C. Do not freeze.

Uniprot ID

O75791

Purification

Protein A purified

Antibody Clonality

Monoclonal

Application Notes

Flow Cytometry Recommended dilution:1 µg/ml Immunoprecipitation Western Blotting