Anti-LARGE1 Monoclonal Antibody (Clone:LARGE-02)

Catalogue Number: 30-1504-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Alias:LARGE1||KIAA0609||LARGE
Shipping Condition:Blue Ice
Unit(s): 0.1 mg
Host name: Mouse
Clone: LARGE-02
Isotype: IgG2b
Immunogen: Recombinant fragment of human LARGE1 (amino acids 35-142)
Application: FACS, WB

Description

Description: LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.

Additional Text

Storage Note

Store at 2-8°C. Do not freeze.

Uniprot ID

O95461

Gene ID

9215

Purification

Protein A purified

Gene Name

LARGE1

Antibody Clonality

Monoclonal