Description: PDE8a (high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 A) is a cyclic nucleotide phosphodiesterase, which hydrolyzes cAMP, an important regulator and mediator of multiple cellular responses to extracellular signals. It is expressed in a wide variety of tissues including testis, ovary, small intestine, and colon. It is not expressed e.g. in thymus. PDE8a is composed of C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
Additional Text
Gene Name
PDE8A
Storage Note
Store at 2-8°C. Do not freeze.
Uniprot ID
O60658
Gene ID
5151
Purification
Protein A purified
Antibody Clonality
Monoclonal
Application Notes
Western blotting: Recommended dilution: 1-2 µg/ml.