PE Conjugated Anti-LARGE1 Monoclonal Antibody (Clone:LARGE-02)
Catalogue Number: 30-2346-ABO
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | LARGE1||KIAA0609||LARGE |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | Mouse |
| Clone: | LARGE-02 |
| Isotype: | IgG2b |
| Immunogen: | Recombinant fragment of human LARGE1 (amino acids 35-142) |
| Application: | FACS |
Description
Description: LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.
Additional Text
Gene ID
9215
Uniprot ID
O95461
Gene Name
LARGE1
Antibody Clonality
Monoclonal
Storage Note
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
30-2346 Datasheet
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