PE Conjugated Anti-LARGE1 Monoclonal Antibody (Clone:LARGE-02)

Catalogue Number: 30-2346-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Conjugated
Alias:LARGE1||KIAA0609||LARGE
Shipping Condition:Blue Ice
Unit(s): 0.1 mg
Host name: Mouse
Clone: LARGE-02
Isotype: IgG2b
Immunogen: Recombinant fragment of human LARGE1 (amino acids 35-142)
Application: FACS

Description

Description: LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.

Additional Text

Gene ID

9215

Uniprot ID

O95461

Gene Name

LARGE1

Antibody Clonality

Monoclonal

Storage Note

Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.